СУБХРОНИЧЕСКОЕ ВВЕДЕНИЕ L-КАРНИТИНА УЛУЧШАЕТ ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ СКЕЛЕТНОЙ МЫШЦЫ БЫСТРОГО ТИПА В ЭКСПЕРИМЕНТАХ НА КРЫСАХ
DOI:
https://doi.org/10.5281/zenodo.22786254Ключевые слова:
скелетная мышца, мышечное сокращение, мышечная работоспособность, L карнитин, крысыЛицензия
Аннотация
На крысах изучена эффективность L-карнитина (100 мг/кг/сутки, внутрибрюшинно, на протяжении 10, 30 и 60 суток) в улучшении функциональных параметров m. tibial anterior.
Субхроническое введение L-карнитина достоверно (р<0,05 относительно контроля) повышает устойчивость мышцы к утомлению и ускоряет восстановление ее сократительной функции после интенсивной нагрузки и через 30–60 суток применения обеспечивает улучшение параметров тетанического сокращения: увеличение скорости развития тетануса (на 46–163 %), силы тетанического сокращения (на 163–295 %), продолжительности максимальной (на 49–55 %) и субмаксимальной (на 65–69 %) работоспособности и сокращение послететанического полурасслабления (на 55–57 %). Полученные данные позволяют рассматривать L-карнитин как перспективное средство повышения работоспособности мышц и ускорения их восстановления после нагрузок.
Скачивания
Библиографические ссылки
1. Evans, A.M., Fornasini, G. Pharmacokinetics of L-carnitine // Clin. Pharmacokinet. – 2003. – V. 42. – Р. 941-967. – DOI: 10.2165/00003088-200342110-00002
2. Georges, B., Le Borgne, F., Galland, S., Isoir, M., Ecosse, D., Grand-Jean, F., Demarquoy, J. Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate // Biochem. Pharmacol. – 2000. – V. 59. – Р. 1357–1363. – DOI: 10.1016/S0006-2928(00)00110-1
3. Виноградов, И.В., Блохин, А.В., Афанасьева, Л.М., Габлия, М.Ю., Дендеберов, Е.С., Капто, А.А., Алексеев, Р.А. Опыт применения L−карнитина в лечении секреторного бесплодия у мужчин (обзор литературы) // Андрология и генитальная хирургия. – 2009. – № 2. – С. 19-22. – EDN: KUYIRP
4. Захарова, И.Н., Творогова, Т.М. Возможности применения препаратов карнитина в педиатрической практике // Российский вестник перинатологии и педиатрии. – 2008. – № 4. – С. 88-93. – URL: https://cyberleninka.ru/article/n/vozmozhnosti-primeneniya-preparatov-karnitina-v-pediatricheskoy-praktike?ysclid=mrze49bo4i669497804
5. Naderi Noreini, S., Malmir, M., Ghafarizadeh, A., Faraji, T., Bayat, R. Protective effect of L-carnitine on apoptosis, DNA fragmentation, membrane integrity and Lipid peroxidation of spermatozoa in the asthenoteratospermic men // Andrologia. – 2021. – V. 53, No. 2. – Р. e13932. – DOI: 10.1111/and.13932
6. Nachvak, S.M., Shabanpur, M., Mostafai, R., Heidari, M.R. L-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trial // J. Arch. Physiol. Biochem. – 2023. – V. 129, No. 1. – Р. 61-68. – DOI: 10.1080/13813455.2020.1797102
7. Chiechio, S., Canonico, P., Grilli, M. L-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug // Int. J. Mol. Sci. – 2018. – V. 19, No. 11. – Р. 11-13. – DOI: 10.3390/ijms19010011
8. Gnoni, A., Longo, S., Gnoni, G.V., Giudetti, A.M. Carnitine in human muscle bioenergetics: can carnitine supplementation improve physical exercise? // Molecules. – 2020. – V. 25, No. 1. – Р. 182. – DOI: 10.3390/ molecules25010182
9. Kelek, S.E., Afşar, E., Akçay, G., Danışman, B., Aslan, M. Effect of chronic L-carnitine supplementation on carnitine levels, oxidative stress and apoptotic markers in peripheral organs of adult Wistar rats // Food Chem. Toxicol. – 2019. – V. 134. – Р. 110851. – DOI: 10.1016/j.fct.2019.110851
10. Ravikumar, S., Prabhu, S., Vani, R. Effects of L-carnitine on the erythrocytes of stored human blood // Transfus. Med. – 2020. – V. 30, No. 3. – Р. 215-225. – DOI: 10.1111/tme.12645
11. Stephens, F.B., Constantin-Teodosiu, D., Greenhaff, P.L. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle // J. Physiol. – 2007. – V. 581. – Р. 431-444. – DOI: 10.1113/jphysiol.2006.125799
12. Байтингер, В.Ф., Логвинов, С.В., Серяков, В.И., Мустафина, Л.Р. Реиннервация скелетной мышечной ткани после микрохирургического шва под влиянием карнитина (экспериментальное исследование) // Вопросы реконструктивной и пластической хирургии. – 2010. – № 3(34). – С. 25-26. – DOI: 10.52581/1814-1471/87/03
13. De Angelis, C.C., Scarfo, C., Falcinelli, M., Perna, E., Ramacci, M.T., Angelucci, L. Age- and trauma-dependent modifications of neuromuscular junction and skeletal muscle structure in the rat. Effects of long-term treatment with Acetyl-L-Carnitine // Mech. Ageing Dev. – 1995. – V. 85, No. 1. – Р. 37-53. – DOI: 10.1016/0047-6374(95)01615-8
14. Maruyama, T., Maruyama, N., Higuchi, T., Nagura, Ch., Takashima, H., Kitai, M., Utsunomiya, K., Tei, R., Furukawa, T., Yamazaki, T., Okawa, E., Ando, H., Kikuchi, F., Abe, M. Efficacy of L-carnitine supplementation for improving lean body mass and physical function in patients on hemodialysis: a randomized controlled trial // Eur. J. Clin. Nutr. – 2019. – V. 73, No. 2. – Р. 293-301. – DOI: 10.1038/S41430-018-0348-Y
15. Руководство по проведению доклинических исследований лекарственных средств / А.Н. Миронова, Н.Д. Бунатян, ред. – Москва: Минздрав РФ, ЗАО «Гриф и К», 2012. – 944 с. – URL: https://rsmu.ru/fileadmin/templates/DOC/Zakon_RF/Mironov_Rukovodstvo_po_provedeniju_doklinicheskikh_issledovanii_lekarstvennykh_sredstv.pdf?ysclid=mrze7klolk615481501
16. Труш, В.В., Соболев, В.И. Эффекты длительно вводимой -липоевой кислоты на нервно-мышечный аппарат в модельных экспериментах на животных // Ученые записки Крымского федерального университета имени В.И. Вернадского Биология. Химия. – 2019. – Т. 5(71), № 4. – С. 158-181. – URL: https://cyberleninka.ru/article/n/effekty-dlitelno-vvodimoy-a-lipoevoy-kisloty-na-nervno-myshechnyy-apparat-v-modelnyh-eksperimentah-na-zhivotnyh?ysclid=mrze8n08lh438164249
17. Galea, V., De Bruin, H., Cavasin, R., McComas, A.J. The number and relative size of motor unites estimated by computer // Muscle and Nerve. – 1991. – V. 14. – Р. 1123-1130. – DOI: 10.1002/mus.880141114
18. Rebouche, C.J. Carnitine. In: Shils M.E., Shike M., Ross A.C., Caballero B., Cousins R.J., eds. Modern Nutrition in Health and Disease. – 10th ed. – Philadelphia: Lippincott, Williams & Wilkins, 2006. – Р. 537-544.
19. Parnetti, L., Gaiti, A., Mecocci, P., Cadini, D., Senin, U. Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type // Eur. J. Clin. Pharmacol. – 1992. – V. 42. – Р. 89–93. – DOI: 10.1111/j.1471-4159.2010.06764
20. MacIntosh, B.R., Gardiner, Ph.F., McComas, A.J. Skeletal muscle. Form and function. – 2th ed. Champaign: Human Kinetics, 2006. – 423 р. – DOI:10.5040/9781492596912
21. Клетикова, Л.В., Пронин, В.В., Каминская, А.А. Влияние карнитин-содержащего комплекса на морфоструктуру мышечной ткани японских перепелов // Ветеринария и кормление. – 2021. – № 6. – С. 24-27. – EDN: FQZOTO – DOI: 10.30917/ATT-VK-1814-9588-2021-6-6
22. Sawicka, A.K., Renzi, G., Olek, R.A. The bright and the dark sides of L-carnitine supplementation: a systematic review // J. Int. Soc. Sports Nutr. – 2020. – V. 17. – Р. 49. – DOI: 10.1186/s12970-020-00377-2
23. Nakamura, J., Koh, N., Sakakibara, F., Hamada, Y., Wakao, T., Hara, T., Mori, K., Nakashima, E., Naruse, K., Hotta, N. Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats // Eur. J. Pharmacol. – 1995. – V. 294, No. 1. – Р. 207-214. – DOI: 10.1016/0014-2999(95)00531-5
24. Soneru, I.L., Khan, T., Orfalian, Z., Abraira, C. Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes // Endocr. Res. – 1997. – V. 23, No. 1-2. – Р. 27-36. – DOI: 10.1080/07435809709031840.
25. Pekala, J., Patkowska-Sokola, B., Bodkowski, R. L-carnitine — metabolic functions and meaning in humans life // Curr. Drug Metab. – 2011. – V. 12. – Р. 667-678. – DOI: 10.2174/138920011796504536
26. Wall, B.T., Stephens, F.B., Constantin-Teodosiu, D. Chronic oral ingestion of l-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans // Int. J. Sport Nutr. Exerc. Metab. – 2011. – V. 21, No. 5. – Р. 385-397. – DOI: 10.1136/jphysiol.2010.201343
27. Drăgan, G.I., Wagner, W., Ploeşteanu, E. Studies concerning the ergogenic value of protein supply and L-carnitine in elite junior cyclists // Physiologie. – 1988. – V. 25. – Р. 129–132. – DOI: 10.1515/physiol-1988-0211
28. Marconi, C., Sassi, G., Carpinelli, A., Cerretelli, P. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes // Eur. J. Appl. Physiol. Occup. Physiol. – 1985. – V. 54. – Р. 131–135. – DOI: 10.1007/BF02335919
29. Greig, C., Finch, K.M., Jones, D.A., Cooper, M., Sargeant, A.J., Forte, C.A. The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity // Eur. J. Appl. Physiol. Occup. Physiol. – 1987. – V. 56. – Р. 457–460. – DOI: 10.1007/BF00417775
30. Colombani, P., Wenk, C., Kunz, I., Krähenbühl, S., Kuhnt, M., Arnold, M., Frey-Rindova, P., Frey, W., Langhans, W. Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: A double-blind crossover field study // Eur. J. Appl. Physiol. Occup. Physiol. – 1996. – V. 73. – Р. 434–439. – DOI: 10.1007/BF00334420
31. Novakova, K., Kummer, O., Bouitbir, J., Stoffel, S.D., Hoerler-Koerner, U., Bodmer, M. Effect of L-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians // Eur. J. Nutr. – 2016. – V. 55, No. 1. – Р. 207–217. – DOI: 10.1007/s00394-015-0838-9
32. Morand, R., Bouitbir, J., Felser, A., Hench, J., Handschin, C., Frank, S., Krähenbühl, S. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice // Eur. J. Nutr. – 2014. – V. 53, No. 6. – Р. 1313–1325. – DOI: 10.1007/s00394-013-0631-6
33. Mielgo-Ayuso, J., Pietrantonio, L., Viribay, A., Calleja-González, J., González-Bernal, J., Fernández-Lázaro, D. Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review // Nutrients. – 2021. – V. 13, No. 12. – Р. 4359. – DOI: 10.3390/nu13124359
34. Fielding, R., Riede, L., Lugo, J.P., Bellamine, A. L-carnitine supplementation in recovery after exercise // Nutrients. – 2018. – V. 10, No. 3. – Р. 349. – DOI: 10.3390/nu10030349
35. Jang, J., Park, J., Chang, H., Lim, K. L-carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats // Appl. Physiol. Nutr. Metab. – 2016. – V. 41, No. 12. – Р. 1240–1247. – DOI: 10.1139/apnm-2016-0094
36. Раджабкадиев, Р.М., Коростелева, М.М., Евстратова, В.С., Никитюк, Д.Б., Ханферьян, Р.А. L карнитин: свойства и перспективы применения в спортивной практике // Вопросы питания. – 2015. – Т. 84, № 3. – С. 4–12. – EDN: UBEKZT.
37. Karlic, H., Lohninger, A. Supplementation of L-carnitine in athletes: does it make sense? // Nutrition. – 2004. – V. 20, No. 7-8. – Р. 709–715. – DOI: 10.1016/J.NUT.2004.04.003
38. Gomes, M.R., Tirapegui, J. Relacao de alguns suplementos nutricionais e o desempenho fisico // Arch. Latinoam. Nutr. – 2000. – V. 50, No. 4. – Р. 317-329. – DOI: 10.37527/2000.50.4.001
39. Kaczor, J.J., Ziolkowski, W., Antosiewicz, J., Hac, S. The effect of aging on anaerobic and aerobic enzyme activities in human skeletal muscle // J. Gerontol. A. Biol. Sci. Med. Sci. – 2006. – V. 61, No. 4. – Р. 339-344. – DOI: 10.1093/gerona/61.4.339
40. Varney, J.L., Fowler, J.W., Gilbert, W.C., Coon, C.N. Utilisation of supplemented L-carnitine for fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers // J. Nutr. Sci. – 2017. – V. 6. – Р. е8. – DOI: 10.1017/jns.2017.4
41. Yarizadh, H., Shab-Bidar, S., Zamani, B., Nazary Vanani, A. The Effect of L-Carnitine Supplementation on Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials // Journal of the American College of Nutrition. – 2020. – V. 39, No. 5. – Р. 457-468. – DOI: 10.1080/07315724.2019.1661804.
42. Dubelaar, M.L., Lucas, C.M., Hulsmann, W.C. The effect of L-carnitine on force development of the latissimus dorsi muscle in dogs // J. Card. Surg. – 1991. – V. 6. – Р. 270–275. – DOI: 10.1111/jocs.1991.6.1s.270
43. Hulsmann, W.C., Dubelaar, M.L. Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia // Mol. Cell. Biochem. – 1992. – V. 116. – Р. 125–129. – DOI: 10.1007/BF01270579
44. Хуторская, И.А., Шаймарданова, Г.Ф., Балашов, В.П., Абрамов, В.Н., Балашов, А.В., Быстрова, Е.В., Евстифеева, И.А. Морфология скелетных мышц при динамической физической нагрузке и коррекции L-карнитином // Клин. эксп. морфология. – 2024. – Т. 13, № 4. – С. 67–75. – DOI: 10.31088/ CEM2024.13.4.67-75
REFERENCES
1. Evans, A.M., Fornasini, G. (2003) Pharmacokinetics of L-carnitine. Clin. Pharmacokinet. 42, 941-967, doi: 10.2165/00003088-200342110-00002
2. Georges, B., Le Borgne, F., Galland, S., Isoir, M., Ecosse, D., Grand-Jean, F., Demarquoy, J. (2000) Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate. Biochem. Pharmacol. 59, 1357–1363, doi: 10.1016/S0006-2928(00)00110-1
3. Vinogradov I.V., Blokhin A.V., Afanaseva L.M., Gablya M.Y., Dendeberov E.S., Kapto A.A., Alekseev R.A. (2009) Usage of L-carnitine in the treatment of the male infertility (a review). Andrology and genital surgery, 2, 19-22. (In Russian)
4. Zakharova I.N., Tvorogova T.M. Possibilities of using carnitine preparations in pediatric practice. Russian bulletin of perinatology and pediatrics, 4, 88-93. (In Russian)
5. Naderi Noreini, S., Malmir, M., Ghafarizadeh, A., Faraji, T., Bayat, R. (2021) Protective effect of L-carnitine on apoptosis, DNA fragmentation, membrane integrity and Lipid peroxidation of spermatozoa in the asthenoteratospermic men. Andrologia, 53 (2), e13932, doi: 10.1111/and.13932
6. Nachvak, S.M., Shabanpur, M., Mostafai, R., Heidari, M.R. (2023) L-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trial. J. Arch. Physiol. Biochem., 129 (1), 61-68, doi: 10.1080/13813455.2020.1797102
7. Chiechio, S., Canonico, P., Grilli, M. (2018) L-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug. Int. J. Mol. Sci., 19 (11), 11-13, doi: 10.3390/ijms19010011
8. Gnoni, A., Longo, S., Gnoni, G.V., Giudetti, A.M. (2020) Carnitine in human muscle bioenergetics: can carnitine supplementation improve physical exercise? Molecules, 25 (1), 182, doi: 10.3390/ molecules25010182
9. Kelek, S.E., Afşar, E., Akçay, G., Danışman, B., Aslan, M. (2019) Effect of chronic L-carnitine supplementation on carnitine levels, oxidative stress and apoptotic markers in peripheral organs of adult Wistar rats. Food Chem. Toxicol., 134, 110851, doi: 10.1016/j.fct.2019.110851
10. Ravikumar, S., Prabhu, S., Vani, R. (2020) Effects of L-carnitine on the erythrocytes of stored human blood. Transfus. Med., 30 (3), 215-225, doi: 10.1111/tme.12645
11. Stephens, F.B., Constantin-Teodosiu, D., Greenhaff, P.L. (2007) New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J. Physiol., 581, 431-444, doi: 10.1113/jphysiol.2006.125799
12. Baitinger, V.F., Logvinov, S.V., Seryakov, V.I., Mustafina, L.R. (2010) Reinnervation of skeletal muscle tissue after microsurgical suture under the influence of carnitine (experimental study). Voprosy rekonstruktivnoy i plasticheskoy khirurgii [Issues of Reconstructive and Plastic Surgery], 3(34), 25-26, doi: 10.52581/1814-1471/87/03 (In Russian)
13. De Angelis, C.C., Scarfo, C., Falcinelli, M., Perna, E., Ramacci, M.T., Angelucci, L. (1995) Age- and trauma-dependent modifications of neuromuscular junction and skeletal muscle structure in the rat. Effects of long-term treatment with Acetyl-L-Carnitine. Mech. Ageing Dev., 85 (1), 37-53, doi: 10.1016/0047-6374(95)01615-8
14. Maruyama, T., Maruyama, N., Higuchi, T., Nagura, Ch., Takashima, H., Kitai, M., Utsunomiya, K., Tei, R., Furukawa, T., Yamazaki, T., Okawa, E., Ando, H., Kikuchi, F., Abe, M. (2019) Efficacy of L-carnitine supplementation for improving lean body mass and physical function in patients on hemodialysis: a randomized controlled trial. Eur. J. Clin. Nutr., 73 (2), 293-301, doi: 10.1038/S41430-018-0348-Y
15. Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv (Guidelines for conducting preclinical studies of medicines), A.N. Mironova, N.D. Bunatyan, eds. Moscow: Minzdrav RF, ZAO «Grif i K», 2012. 944 р. (In Russian)
16. Trush V.V., Sobolev V.I. (2019) Effects of long-term administration of α-lipoic acid on the neuromuscular apparatus in animal experiments. Uchenyye zapiski Krymskogo federal'nogo universiteta imeni V.I. Vernadskogo Biologiya. Khimiya [Scientific Notes of the Crimean Federal University named after V.I. Vernadsky Biology. Chemistry], 5(71) (4), 158-181. (In Russian)
17. Galea, V., De Bruin, H., Cavasin, R., McComas, A.J. (1991) The number and relative size of motor unites estimated by computer. Muscle and Nerve, 14, 1123-1130, doi: https://doi.org/10.1002/mus.880141114
18. Rebouche, C.J. Carnitine. In: Shils M.E., Shike M., Ross A.C., Caballero B., Cousins R.J., eds. (2006) Modern Nutrition in Health and Disease. – 10th ed. – Philadelphia: Lippincott, Williams & Wilkins. – Р. 537-544.
19. Parnetti, L., Gaiti, A., Mecocci, P., Cadini, D., Senin, U. (1992) Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin. Pharmacol., 42, 89–93, doi: 10.1111/j.1471-4159.2010.06764
20. MacIntosh, B.R., Gardiner, Ph.F., McComas, A.J. (2006) Skeletal muscle. Form and function. – 2th ed. Champaign: Human Kinetics. – 423 р. – doi:10.5040/9781492596912
21. Kletikova L.V., Pronin V.V., Kaminskaya A.A. (2021) The influence of the carnitine-containing complex on the morphostructure at the muscle tissue of Japanese quail. Veterinaria i kormlenie [Veterinary science and feeding], 6, 24–27.
22. Sawicka, A.K., Renzi, G., Olek, R.A. (2020) The bright and the dark sides of L-carnitine supplementation: a systematic review. J. Int. Soc. Sports Nutr., 17, 49, doi: 10.1186/s12970-020-00377-2
23. Nakamura, J., Koh, N., Sakakibara, F., Hamada, Y., Wakao, T., Hara, T., Mori, K., Nakashima, E., Naruse, K., Hotta, N. (1995) Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats // Eur. J. Pharmacol., 294 (1), 207-214, doi: 10.1016/0014-2999(95)00531-5
24. Soneru, I.L., Khan, T., Orfalian, Z., Abraira, C. (1997) Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes. Endocr. Res., 23 (1-2), 27-36, doi: 10.1080/07435809709031840.
25. Pekala, J., Patkowska-Sokola, B., Bodkowski, R. (2011) L-carnitine — metabolic functions and meaning in humans life. Curr. Drug Metab., 12, 667-678, doi:10.2174/138920011796504536
26. Wall, B.T., Stephens, F.B., Constantin-Teodosiu, D. (2011) Chronic oral ingestion of l-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. Int. J. Sport Nutr. Exerc. Metab., 21 (5), 385-397, doi: 10.1136/jphysiol.2010.201343
27. Drăgan, G.I., Wagner, W., Ploeşteanu, E. (1988) Studies concerning the ergogenic value of protein supply and L-carnitine in elite junior cyclists. Physiologie, 25, 129–132, doi: 10.1515/physiol-1988-0211
28. Marconi, C., Sassi, G., Carpinelli, A., Cerretelli, P. (1985) Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur. J. Appl. Physiol. Occup. Physiol., 54, 131–135, doi: 10.1007/BF02335919
29. Greig, C., Finch, K.M., Jones, D.A., Cooper, M., Sargeant, A.J., Forte, C.A. (1987) The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. Eur. J. Appl. Physiol. Occup. Physiol., 56, 457–460, doi: 10.1007/BF00417775
30. Colombani, P., Wenk, C., Kunz, I., Krähenbühl, S., Kuhnt, M., Arnold, M., Frey-Rindova, P., Frey, W., Langhans, W. (1996) Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: A double-blind crossover field study. Eur. J. Appl. Physiol. Occup. Physiol., 73, 434–439, doi: 10.1007/BF00334420
31. Novakova, K., Kummer, O., Bouitbir, J., Stoffel, S.D., Hoerler-Koerner, U., Bodmer, M. (2016) Effect of L-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. Eur. J. Nutr., 55 (1), 207–217, doi: 10.1007/s00394-015-0838-9
32. Morand, R., Bouitbir, J., Felser, A., Hench, J., Handschin, C., Frank, S., Krähenbühl, S. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur. J. Nutr., 53 (6), 1313–1325, doi: 10.1007/s00394-013-0631-6
33. Mielgo-Ayuso, J., Pietrantonio, L., Viribay, A., Calleja-González, J., González-Bernal, J., Fernández-Lázaro, D. (2021) Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review. Nutrients, 13 (12), 4359, doi: 10.3390/nu13124359
34. Fielding, R., Riede, L., Lugo, J.P., Bellamine, A. (2018) L-carnitine supplementation in recovery after exercise. Nutrients, 10 (3), 349, doi: 10.3390/nu10030349
35. Jang, J., Park, J., Chang, H., Lim, K. (2016) L-carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats. Appl. Physiol. Nutr. Metab., 41 (12), 1240–1247, doi: 10.1139/apnm-2016-0094
36. Radzhabkadiev, R.M., Korosteleva, M.M., Evstratova, V.S., Nikityuk, D.B., Khanferyan, R.A. (2015) L-carnitine: properties and prospects for use in sports practice. Voprosy pitaniya [Nutrition Issues], 84 (3), 4–12. Available at: https://www. elibrary.ru/item.asp?id=23816223
37. Karlic, H., Lohninger, A. (2004) Supplementation of L-carnitine in athletes: does it make sense? Nutrition, 20 (7-8), 709–715, doi: 10.1016/J.NUT.2004.04.003
38. Gomes, M.R., Tirapegui, J. (2000) Relacao de alguns suplementos nutricionais e o desempenho fisico. Arch. Latinoam. Nutr., 50 (4), 317-329, doi: 10.37527/2000.50.4.001
39. Kaczor, J.J., Ziolkowski, W., Antosiewicz, J., Hac, S. (2006) The effect of aging on anaerobic and aerobic enzyme activities in human skeletal muscle. J. Gerontol. A. Biol. Sci. Med. Sci., 61 (4), 339-344, doi: 10.1093/gerona/61.4.339
40. Varney, J.L., Fowler, J.W., Gilbert, W.C., Coon, C.N. (2017) Utilisation of supplemented L-carnitine for fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers. J. Nutr. Sci., 6, е8, doi: 10.1017/jns.2017.4
41. Yarizadh, H., Shab-Bidar, S., Zamani, B., Nazary Vanani, A. (2020) The Effect of L-Carnitine Supplementation on Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of the American College of Nutrition, 39 (5), 457-468, doi: 10.1080/07315724.2019.1661804
42. Dubelaar, M.L., Lucas, C.M., Hulsmann, W.C. (1991) The effect of L-carnitine on force development of the latissimus dorsi muscle in dogs. J. Card. Surg., 6, 270–275, doi: 10.1111/jocs.1991.6.1s.270
43. Hulsmann, W.C., Dubelaar, M.L. (1992) Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia. Mol. Cell. Biochem., 116, 125–129, doi: 10.1007/BF01270579
44. Khutorskaya I.A., Shaymardanova G.F., Balashov V.P., Abramov V.N., Balashov A.V., Bystrova E.V., Evstifeeva I.A. (2024) Morphology of skeletal muscles under dynamic exercise and correction with L-carnitine. Clin. exp. morphology, 2024, 13 (4), 67–75, doi: 10.31088/CEM2024.13.4.67-75 (In Russian)
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Статьи журнала «Вестник Донецкого университета. Серия 01. Естественные науки» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Донецким Государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.
